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In another study, NAC supplementation had no significant effect on serum levels of sex hormone-binding globulin (SHBG), LH, FSH, LH/FSH, E2 and testosterone in PCOS patients after 12 weeks (Reference Ghomian, Khadem and Moeindarbari5,Reference Nasr9,Reference Nemati, Nemati and Taheri12,Reference Badawy, State and Abdelgawad13)

Contraindications include active or recent cancer, uncontrolled diabetes, severe diabetic retinopathy, and pregnancy

Available from: [Last accessed on 8 Apr 2024]

Briefly, the extraction uses non-buffered alcohol solution mixture, heated to induce protein unfolding and releasing cofactors while preserving redox-sensitive metabolites