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The resulting caloric deficit and weight loss which can be substantial over the course of treatment, as demonstrated in the SURMOUNT and STEP trial programmes can place considerable physiological stress on the body
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A comprehensive approach considers individual dietary patterns, pre-existing deficiencies, and concurrent medications
Third, the study only included patients whose dose was escalated to 1.0 mg and lacked a control group of patients who maintained the 0.5-mg dose
Oral glutathione has very limited bioavailability and cannot reliably achieve therapeutic plasma concentrations
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