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The animal data on connective tissue are the most cited
Nevertheless, as the simultaneous activation of GLP-1 and GIP receptors in preclinical models results in greater WL and glucose-lowering efficacy compared to activation of each receptor alone [38,39,40], the interest for the development of unimolecular GLP-1 and GIP RA was increased, despite that this additive effect in food intake and glycaemia was not observed in some acute clinical studies [41, 42]
The clinical literature contains no reliable reports of serotonin syndrome associated with 5-HTP, suggesting 5-HTP have low propensity to cause this adverse event in humans
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