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Understanding this mechanism may be important in appreciating the pathophysiology of several diseases, particularly those associated with microbial dysbiosis

This observation means that xCT blockage induces the accumulation of glutamate that is converted into -ketoglutarate instead of being used in glutamate-cysteine exchange and consequently that is why cysteine does not enter the cell and give rise to glutathione

They are related to cellular health, but they are not the same

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