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Neurological symptoms may start improving within 12 weeks, but longstanding complications can require 36 months of treatment, with some damage potentially irreversible
Sig Transduct Target Ther 5, 227 (2020)
Yes, and it is often advisable for long-term users
Immediate reactions to high-dose B12 Healthcare professionals typically use vitamin B12 amounts of 1,000 mcg and higher to treat a deficiency
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