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This is consistent with studies showing that HA can improve the performance of nanoparticle-based drug formulations by extending local retention and reducing systemic absorption [1]
For example, TNF activity reduces both ATGL and HSL expression at the level of the gene but induces increased lipase activity of pre-existing enzyme resulting in fatty acid and glycerol release from triglycerides
This might lead to subtle imbalances that are not immediately obvious
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