maintain weight after semaglutide 💉 GLP-1 medications are changing obesity treatment—but are they enough? and tirzepatide have revolutionized management and diabetes care by helping patients lose weight and improve blood sugar control. But sustainable Those discontinuing GLP-1 medications rapidly

doi: 10.2337/dc12-2454 72 RosenstockJHanefeldMShamannaPMinKWBokaGMiossecPet al

Hepatic saturated fatty acid fraction is associated with de novo lipogenesis and hepatic insulin resistance

Side Effects by the Numbers Nausea How common ~40% Typical duration Peaks within 1 hr, eases over 2-3 hr Flushing How common ~20% Typical duration Transient, under a few hours Injection-site reaction How common ~13% Typical duration Minor, fades same day Headache How common ~11% Typical duration Transient, hours Vomiting How common ~5% Typical duration Early, short-lived Blood-pressure rise How common ~+6/+3 mmHg avg Typical duration Resolves in ~8-12 hr Skin/gum darkening How common ~1% Typical duration Builds with use, may persist Kingsberg SA et al., "Bremelanotide for the Treatment of Hypoactive Sexual Desire Disorder" (RECONNECT Phase III trials), Obstet Gynecol, 2019

Changes in the activities and mRNA expression levels of lipoprotein lipase (LPL), hormone-sensitive lipase (HSL) and fatty acid synthetase (FAS) of Nile tilapia ( Oreochromis niloticus ) during fasting and re-feeding