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Gene expression profiling revealed distinct apoptotic pathways: low-dose exposure triggers apoptosis through cellular stress responses, while high-dose exposure primarily activates it via direct DNA damage (160)
SIRT1, localized in the nucleus, deacetylases and activates proliferator-activated receptor gamma coactivator-1 (PGC-1), which leads to increased mitochondrial biogenesis 103
f-i , Representative H&E staining of skeletal muscle (quadriceps) (f,g) and liver (h,i) from Het (f,h) and KO (g,i) mice on Days 3 and 7 of calorically restricted Ctrl or No Cys diets (n = 4 per group)
Sirt3 deficiency accelerates ovarian senescence without affecting spermatogenesis in aging mice [J]
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