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17-estradiol production from the ovarian follicles declines further after 35 years of age, and there is a progressive decline in estrogen levels at 4045 years of age [10] (Fig

Furthermore, a dual luciferase reporter system assay demonstrated that the luciferase activity of GGCT-3 untranslated region (UTR) (wild-type) decreased after transfection with miR-29b-3p mimics, while the luciferase activity of GGCT-3 mUTR (mut) did not show significant changes in MHCC97H and LNCaP cells (Fig

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Spindle abnormalities, common in aged oocytes, appeared to have been mitigated by Epithalon, as was the mislocalization of CGs, which are essential for fertilization