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In November 2023, the FDA granted approval for tirzepatide under the brand name Zepbound for chronic weight management in adults with obesity (BMI 30 kg/m) or overweight (BMI 27 kg/m) with at least one weight-related comorbidity, as an adjunct to a reduced-calorie diet and increased physical activity
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Retatrutide 30MG adds glucagon receptor agonism as a third target
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MOTS-c (mitochondrial-derived peptide) This is an artificial exercise candidate, thought to trigger some of the same cellular responses as exercise, like boosting endurance and improving metabolic health
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