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Another study has demonstrated that diapocynin exhibits a lower IC 50 for NOX2 inhibition (sub-micromolar) compared to parent apocynin, effectively blocking p47^phox^ translocation and attenuating endothelial superoxide generation in isolated vessel assays (Juric et al., 2023)
Our findings do not exclude a positive role for endosomal signaling or -arrestin-1 recruitment in acute responses to physiological GLP-1, but highlight how the kinetic context must be taken into account when exploiting noncanonical pathways during drug development
Why does GLP-1 increase heart rate
Both are widely studied in laboratory research involving tissue repair, cellular signalling and regenerative processes
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