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According to Harvard University, Growth hormone (GH) is a small protein that is made by the pituitary gland and secreted into the bloodstream. GH is usually produced at night, with levels increased following exercise, trauma, and sleep, with production declining from middle age
Mechanically the skin becomes stiffer and more fragile with a loss of resilience [24] making aged skin more susceptible to damage
The initial effects of increased collagen and glycosaminoglycan synthesis become apparent
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