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What to Know about Orforglipron: An Investigational Oral GLP-1

Currently approved weight management pharmacotherapy in the UK includes: Semaglutide (Wegovy) a GLP-1 receptor agonist approved by the MHRA for chronic weight management in adults, subject to NICE Technology Appraisal eligibility criteria [3] [5] Tirzepatide (Mounjaro) a dual GIP/GLP-1 receptor agonist approved by the MHRA for the treatment of type 2 diabetes

And now, the other kind of weight loss medications that we talked about earlier - the unregulated and mostly ineffective ones

Patients are encouraged to report any suspected side effects to the MHRA Yellow Card scheme, which helps monitor the safety of medicines