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The accumulation of amphetamines effectively reverses the transporter carrier mechanisms, leading to a massive, non-exocytotic efflux of vesicular dopamine out into the cytosol, where it is subsequently transported into the synaptic cleft (Wimalasena 2011)(see Figure 2 Mechanism B)
However, these mild local and site reactions are generally harmless and resolve independently without any intervention
Lumps or hard spots under the skin Firm lumps, nodules, or hardened areas near injection sites can develop for several reasons
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