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A very large fraction of published binding constants for melanocortin ligands, including those for cyclic analogues, peptidomimetics and candidate subtype-selective compounds, are reported as inhibition of I-NDP-alpha-MSH binding to membranes from cell lines stably expressing a single human receptor subtype

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Berberine can potentiate the effects of metformin, sulfonylureas, and insulin, potentially causing dangerous hypoglycemia