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These metabolite molecules then pass through phase II detoxification to become even more hydrophilic (water-loving) so that they can easily be eliminated
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The MC1R gene is among the most polymorphic in the human genome and with numerous loss-of-function variants associated with red hair, fair skin, increased UV sensitivity, and elevated melanoma risk , and MT-1 is used as a research tool for studying how MC1R polymorphisms influence receptor function, signalling capacity, and downstream melanogenesis and photoprotection biology
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