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Standard titration protocol from clinical trials The Phase 2 NEJM trial used the following escalation schedule for the 12 mg dose group: Weeks 1 through 4: 2 mg once weekly (subcutaneous) Weeks 5 through 8: 4 mg once weekly Weeks 9 through 12: 8 mg once weekly Week 13 and beyond: 12 mg once weekly (maintenance dose) For the 8 mg target dose, the schedule was: Weeks 1 through 4: 2 mg once weekly Weeks 5 through 8: 4 mg once weekly Week 9 and beyond: 8 mg once weekly (maintenance dose) These titration schedules are not suggestions
Numbness or Tingling (Rare) Cause : GH-induced fluid retention can occasionally compress nerves or cause transient neuropathy symptoms
Its key to watch patients closely and adjust treatment if needed
Simply put, DSIP (delta sleep-inducing peptide) is a naturally occurring neuropeptide linked to sleep regulation and overall recovery
