gip and glp 1 receptors This review summarizes how GLP-1 dual GIP/GLP-1 receptor agonists act at the cellular level and their therapeutic applications in metabolic diseases like type 2 diabetes and obesity, highlighting advances in incretin-based Frontiers | Mini Review: Effect

Wewer Albrechtsen NJ, Albrechtsen R, Bremholm L, Svendsen B, Kuhre RE, Poulsen SS, Christiansen CB, Jensen EP, Janus C, Hilsted L, Deacon CF, Hartmann B, and Holst JJ

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In animals, GLP-1R engagement was demonstrated through glucose-tolerance, food-intake, and gastric-emptying readouts, while GCGR engagement was tracked through liver nicotinamide N-methyltransferase (NNMT) messenger-RNA expression and circulating biomarkers including amino acids and fibroblast growth factor-21 (FGF-21)