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Higher doses (90 mg and 120 mg) achieved up to 12.2% mean reduction from baseline (26.6 lbs) versus 1.3% (2.9 lbs) for placebo, with up to 97% of patients losing 5% of body weight

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Biochemical characteristics of blood sample including fasting blood sugar, hemoglobin A1c (HbA1c), total cholesterol, low density lipoprotein (LDL)-cholesterol, high density lipoprotein (HDL)-cholesterol levels, high sensitivity C-reactive protein (hsCRP), obesity-related hormone peptides, and HRQOL scores on the WHOQOL-BREF were also assessed

The superior metabolic benefits observed with concomitantly targeting GLP-1 and GIP receptors garnered interest in developing unimolecular drugs that would combine the actions of GLP-1 and GIP (Figure 1)