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It may also trigger adaptive metabolic responses that slow weight loss over time and increase the likelihood of weight regain after treatment cessation

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Mitochondrial dysfunction plays a key role in the development of neurodegenerative diseases in diabetes

[9] [10] Classification [edit] Protein sequence and structure are important additional classification criteria for the three superfamilies (cytosolic, mitochondrial, and MAPEG) of GSTs: while classes from the cytosolic superfamily of GSTs possess more than 40% sequence homology, those from other classes may have less than 25%