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Improved glucose control and reduced body weight in rodents with dual mechanism of action peptide hybrids

Younus F, Chertemps T, Pearce SL, Pandey G, Bozzolan F, Coppin CW

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Key findings from the preclinical data: Retatrutide produced dose-dependent delayed gastric emptying Semaglutide also produced dose-dependent delayed gastric emptying The combination of retatrutide and semaglutide did not produce statistically significant differences compared to retatrutide alone In plain terms: adding semaglutide to retatrutide did nothing measurable in this specific endpoint