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In animal models, L-theanine appears to have a dose-dependent biphasic effect on NSAID-induced gastric ulcers, delaying healing at higher doses (40 mg/kg), but accelerating healing at lower doses (10 mg/kg) perhaps through the maintenance of glutathione levels thus protecting against oxidative damage (26)
Although the FDA acknowledged that additional adverse event reports received prior to its inspection were submitted retroactively, the agency still deemed adverse event reporting procedures deficient
Acevedo HF (2002)
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