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Screening techniques for DPN, such as the 10-g monofilament and assessment of touch, vibration sense, and ankle reflexes, have limitations, primarily detecting advanced neuropathy and missing early stages, especially those associated with small fiber abnormalities and neuropathic pain [14, 17,18,19,20,21,22]
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"Poly-agonist approaches to metabolic disease: mechanisms and clinical potential." Obesity
For instance, poly(N-isopropylacrylamide) (pNIPAM) can be grafted onto liposomal surfaces to achieve thermo-responsiveness, whereas gold nanoparticles can be included within or affixed to liposomes for photo-triggered release through plasmonic heating [92]
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