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The largest increases in first-time CVD diagnosis following first-time GLP-1 RA prescription were seen in the group of people having overweight or BMIs between 27 to 30 (34.5% increase from 2020 to 2024)

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after 12 months mean = 1.05, SD = 0.4, N = 10 for both, P = 0.0253)

Early studies suggest they can shift the balance of gut bacteria, but findings in humans are still mixed, with more research being needed in this area as we dont know if the effects are positive or negative! GLP-1s can boost beneficial gut bacteria A review of available studies explored the specific effects of different GLP-1 receptor agonists on the gut