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Modulated expression of 4,000+ human genes in cultured fibroblasts Upregulated antioxidant genes including SOD and glutathione peroxidase Downregulated pro-inflammatory and tissue-destructive gene networks Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data2014Gene Expression Analysis using the Broad Institute Connectivity Map reveals GHK-Cus gene expression signature overlaps with tissue-remodeling, anti-cancer, and neuroprotective pathways, extending its potential research applications

The studys limitationsmall sample sizes without large-scale RCT confirmationmatters for clinical translation but doesnt negate the mechanistic evidence

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