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In addition to the genetic mutations that predispose individuals to hepatic fibrosis that appear in childhood, mutations of the PNPLA3 gene have been described as a major predisposing factor in non-alcoholic fatty liver disease (NAFLD) ( PNPLA3 encodes for Patatin-like phospholipase domain-containing protein 3 or adiponutrin and is abundantly expressed in hepatocytes, adipocytes as well as HSCs (Dong, 2019)

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