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The and classes of GSTs play a regulatory role in the mitogen-activated protein (MAP) kinase pathway that participates in cellular survival and death signals via protein : protein interactions with c-Jun N-terminal kinase 1 (JNK1) and ASK1 (apoptosis signal-regulating kinase)

Additionally, the review will discuss the primary sources of oxidative stress in spermatozoa, including mitochondrial dysfunction, leukocyte activation, and environmental/lifestyle factors

However, free radicals have some good effects as well