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In ovariectomized mice (an animal model for menopause), estrogen replacement increased GLP-1 secretion from both intestinal L-cells and pancreatic alpha-cells
Future studies using other transgenic mouse models will be useful in determining the exact path-way by which paracetamol causes liver damage and may therefore provide novel therapeutic strategies by which to reverse liver damage in patients who present late after paracetamol overdosage
Thus, incubating human and rodent islets under high glucose conditions results in increased expression of PC1/3 and increased secretion of GLP-1 (101, 108110), while exposure of -cells to the proinflammatory cytokine, interleukin-6, also increased GLP-1 secretion (112)
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