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Abbreviations and Acronyms ANCOVA = analysis of covariance CKD = chronic kidney disease eGFR = estimated glomerular filtration rate EQ-5D-5L = EuroQol 5-Dimensions 5-Level GLP = glucagon-like peptide HFpEF = heart failure with a preserved ejection fraction hsCRP = high-sensitivity C-reactive protein KCCQ-CSS = Kansas City Cardiomyopathy Questionnaire Clinical Summary Score NT-proBNP = N-terminal proB-type natriuretic peptide PGIS = Patient Global Impression of Severity Overall Health SGLT2 = sodium-glucose cotransporter 2 UACR = urinary albumin-creatinine ratio Funding Support and Author Disclosures Dr Packer has served as a consultant for 89bio, AbbVie, Actavis, Altimmune, Alnylam, Amarin, Amgen, Ardelyx, ARMGO, AstraZeneca, Attralus, Biopeutics, Boehringer Ingelheim, Caladrius, Casana, CSL Behring, Cytokinetics, Lilly, Imara, Medtronic, Moderna, Novartis, Pharmacocosmos, Reata, Regeneron, Roche, and Salamandra