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Additionally, semaglutide slows gastric emptying (though this effect may attenuate with chronic dosing) and acts on appetite centres in the brain to reduce food intake
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GIP receptor activation in adipose tissue influences lipid storage and mobilization, and in the brain, it contributes to appetite regulation through mechanisms that complement GLP-1 signaling
Additional screening and caution considerations Other medical situations that require careful evaluation include: History of pancreatitis GLP-1 receptor agonists are generally used with caution in people with a history of treated pancreatitis
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