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If not neutralized by antioxidants, ROS may damage mitochondria over time, causing them to function less efficiently and to generate more damaging ROS in a self-perpetuating cycle
NAD+ remains experimental , with promising preclinical data and case reports, but no large-scale human trials yet
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Alteration of the redox balance is a key factor in HIV-1 pathogenicity, including neurotoxicity and dementia, depletion of CD4 + /CD8 + T cells, susceptibility to lung infections, and side effects of antiretroviral therapy 111
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