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Per ADA 2026 Standards of Care, treatment is individualized based on A1C targets, comorbidities (CVD, CKD, heart failure), hypoglycemia risk, weight effects, cost, and patient preference

The number and phenotype of macrophages in atherosclerotic plaques are intimately linked to the diseases onset and progression

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Restarting treatment after regain is common and usually effective, though some patients respond less robustly the second time