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Participants had moderate to severe fibrosis (F2-F3), not cirrhosis (F4) A separate trial in patients with cirrhosis showed semaglutide didnt significantly improve fibrosis in that population Maintaining improvements likely requires ongoing weight management For fibrosis, about 37% of participants showed improvement of at least one stage
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Am J Physiol Endocrinol Metab (2009) 297:E135865.10.1152/ajpendo.00412.2009 182 NielsenLBPlougKBSwiftPOrskovCJansen-OlesenIChiarelliFet alCo-localisation of the Kir6.2/SUR1 channel complex with glucagon-like peptide-1 and glucose-dependent insulinotrophic polypeptide expression in human ileal cells and implications for glycaemic control in new onset type 1 diabetes
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