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For example, GSTs having a serine (or tyrosine) as a catalytic residue catalyze a wide range of reactions involving the conjugation of glutathione (GSH

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It falls far short of the appropriate design for a clinical trial safety test that might use 3 pulses of 0.5 mg each to test safety in humans before proceeding with incremental higher doses

For example, an observational study is evaluating predictive biomarkers in patients with advanced HCC treated with atezolizumab plus bevacizumab, and another study is assessing predictive biomarkers in patients receiving systemic therapy for advanced HCC (37, 38)