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Published studies using Horvath-clock and DNAm GrimAge epigenetic aging measurements have found that MTHFR C677T T/T status is associated with accelerated epigenetic aging biological age running ahead of chronological age with effect sizes that are modest at adequate folate intake but become more pronounced under folate insufficiency

These models provide insight into how AOD 9604 influences the partitioning of energy substrates between storage and oxidation, particularly within adipose tissue

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