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It is considered to be the key mechanism of ROS-induced sperm damage and leads to Loss of sperm motility Abnormal sperm morphology Reduced capacity for oocyte penetration Infertility To protect sperm from damage, the body depends on powerful antioxidant enzymes in the body such as superoxide dismutase (SOD), catalase, and glutathione peroxidase/reductase (GPX/GRD)

It's whether the evidence of benefit outweighs the evidence of harm at a population scale, across diverse patients, over meaningful time horizons

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