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Insulin resistance, a known GH effect at supraphysiologic levels, compounds the glucose dysregulation already present in cirrhosis-related diabetes (hepatogenous diabetes affects approximately 30% of cirrhotic patients, per data in the Journal of Diabetes Research)
Frontal cortex concentrations increased by 50% from 2016 to 2024, with dementia cases exhibiting higher accumulation than controls (Nihart et al., 2025)
Its targeted receptor activity makes it a valuable compound for precision hormone pathway studies
Changes in gene expression, proteostasis, matrix markers, or senescence-associated measurements do not establish age reversal or anti-aging outcomes
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