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Dose-limiting toxicity has not been precisely defined in humans, yet practitioners should terminate infusions if severe dizziness, chest tightness, or abrupt blood-pressure drops occur, then reassess electrolyte status and acid-base balance before re- challenge

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Bioinformatics 27:27722773

The receptor for this response, innate repair receptor (IRR) is a member of the type I cytokine receptor family and is a complex consisting of common receptor (CD131) and erythropoietin (EPO) receptor subunits (3)