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The precise mechanisms underlying MSC homing and localization in the kidney are still being studied, but it is thought to be related to interactions with adhesion molecules, chemokines, and cytokines present in the injured tissue
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Moreover, linagliptin has been shown to increase circulating SDF-1, as well as putative vascular regenerative and anti-inflammatory cells in patients with T2DM, independently of its effects on glycemia [201, 202]
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