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It is very hygroscopic in the anhydrous form, and sparingly soluble in water (1:80)
A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique
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This means that the patient has a nerve injury causing severe pain and weakness that is not improving, or is worsening over a short period
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