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Presented for research literature review only Lo Giudice P et al

5 Evidence indicates that patients with TED produce autoantibodies that stimulate this receptor complex, causing hyperactivation of orbital fibroblasts and immune cells which mediate the disease process in susceptible individuals

However, in the case of selenoprotein messenger ribonucleic acid (mRNA), the 3untranslated region contains selenocysteine insertion sequence (SECIS) elements, which allow for the recognition of UGA as a selenium cysteine codon rather than a stop signal (21)

Patients considering IGF-1 LR3 should undergo comprehensive evaluation to determine whether peptide therapy is appropriate and whether safer alternatives may achieve similar goals