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Simultaneously targeting tissue transglutaminase and kidney type glutaminase sensitizes cancer cells to acid toxicity and offers new opportunities for therapeutic intervention

Following the catabolism of glucose in the cytoplasm as part of glycolysis, the generated pyruvate is transported to the mitochondrial matrix, where it feeds into the TCA, undergoing oxidation to reduce NAD + to NADH, which is the main electron donor of the ETC 87

Lancet Gastroenterol Hepatol 2023;8:17991.ArticlePubMed 82

Its GLP-1, GIP, and glucagon triple-agonist design makes it an important compound for studying dose-sensitive and early-stage metabolic regulation mechanisms.