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This escalation approach is standard across GLP-1 class compounds and serves to improve gastrointestinal tolerability

More recently, a 2011 trial involving more than 35,500 men over 50 found that large doses of vitamin E increased the risk of prostate cancer by 17 percent

However, the lack of clinical trial data specifically on microdosing means the safety profile at ultra-low doses has not been formally characterized

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