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Patients often report increased energy within the first week due to L-carnitines mitochondrial effects, but weight loss velocity accelerates most significantly between weeks 4 and 8 as hepatic steatosis resolves and VLDL export normalizes
Additionally, the SMR analysis revealed that each one-standard-deviation increase in GLP1R gene expression was associated with a reduced risk of anxiety, while no significant associations were found between GLP1R gene expression and other mood disorder-related ADRs
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