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All-cause mortality occurred in 8.6 percent of patients in the tirzepatide group compared with 10.2 percent in the dulaglutide group, corresponding to a hazard ratio of 0.84

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Nothing available over the counter produces a clinically meaningful increase in growth hormone or IGF-1

Semaglutide, however, has the most mature evidence for cardiovascular risk reduction, as demonstrated in the SUSTAIN-6, PIONEER-6, and SELECT trials