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Further analysis revealed that the DEGs, particularly those genes within the PPAR signaling pathway with upregulated expression, such as angiopoietin-like 4 ( ANGPTL4 ), CD36 , FATP1 , fatty acid transport protein 4 ( FATP4 ), and perilipin 2 ( PLIN2 ) in the leg muscles of caged versus free-range Lueyang black-boned chickens, are associated with IMF deposition (Table 1) [56]

Are they safe and effective in the long term

Another double-blinded, placebo-controlled study reported that liraglutide increased intrinsic connectivity in bilateral hippocampal, medial frontal and lateral occipital regions, suggesting that liraglutide might reduce or delay AD progression (245)