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Nausea, constipation, and stomach discomfort are common side effects that some people may encounter, especially during the first few months of treatment
Some of the GLP-1 based medications available on the U.S
At this time, retatrutide is intended for use in an authorized clinical trial or exactly as directed by a healthcare provider
Key Takeaways Tirzepatide vs semaglutide comes down to dual agonist vs single agonist: tirzepatide targets both GLP-1 and GIP receptors, while semaglutide targets GLP-1 alone The only head-to-head trial (SURPASS-2) found tirzepatide superior to semaglutide for both blood sugar control and weight loss In separate obesity trials, tirzepatide 15mg achieved 20.9% weight loss at 72 weeks vs semaglutide 2.4mg's 14.9% at 68 weeks Semaglutide has proven cardiovascular benefit (SELECT trial: 20% MACE reduction)
