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Using the DRSC Integrative Ortholog Prediction Tool 32 , we identified the Drosophila gene cyp18a1 as a putative orthologue of CYP2E1 (Fig
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A dynamic AspArg interaction is essential for catalysis in MPGES1 where mutation of R126 results in loss of PGE synthase activity 40, 41
Nutrient interactions Interactions with vitamin K Dating back to the 1940s, studies in animals found excessive dietary intake of vitamin E was associated with fatal hemorrhaging, which was prevented with vitamin K supplementation
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