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Finally, its worth noting that aging itself disrupts circadian rhythms, but conversely, experimental circadian disruption (e.g., chronic jet-lag in animal models) can shorten lifespan and induce phenotypes of premature aging (Zhang et al., 2025)
Melanocortin receptors: their structure, function, and ligands
The most common neurological side effects are headache (8-14% of patients) and dizziness (4-8% of patients), which are typically mild to moderate and often resolve with continued treatment
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