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This makes injections highly effective for pernicious anaemia and other malabsorption syndromes, including post-gastrectomy states, Crohn's disease affecting the terminal ileum, and certain medications that interfere with B12 uptake

Similar 9-shaped conformation of c-MET has been observed in the crystal structure of c-MET in complex with bacterial invasion protein InlB 24

Computer simulations may also be able to show how the molecule acts in actual biological settings, providing hints for bettering its efficacy and design

While we usually think about low B12 causing anemia, a few case reports describe new or worsened polycythemia - an elevated red cell mass - after B12 administration